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Research Associate Sr | Western Psychiatric Hospital

Description

Our laboratory studies the biochemical and molecular bases of neurodegenerative pathologies in Alzheimer and non-Alzheimer tauopathies, in the human brain and biofluids. Our group applies this knowledge to develop and validate novel biomarkers for clinical and research use, employing highly sensitive mass spectrometric and immunoassay technologies. We focus on developing and evaluating blood and cerebrospinal fluid (CSF) biomarkers that: (i) become abnormal very early in Alzheimer’s disease (AD), enabling diagnosis at the preclinical and prodromal stages; (ii) associate with neuropathological confirmation and predict longitudinal changes; (iii) reflect different aspects of AD pathophysiology (e.g., amyloid, tau, neurodegeneration, glia activation, inflammation and synaptic dysfunction); and (iv) predict future functional and cognitive changes.  

In recent years, we have discovered novel forms of phosphorylated tau in blood and CSF, and have developed and verified new diagnostic tools (some now commercialized and others patented) to quantify these as AD biomarkers suitable for clinical use. These biomarkers have now been validated in dozens of research cohorts and are now widely used for therapeutic trials, diagnosis, prognosis and research studies. 

The Research Associate Sr will perform biomarker analyses in biospecimens from research and clinical participants, following clearly laid out standards of practice, overseen by the PI.  They will also process these data and prepare reports for the collaborating studies. Furthermore, the candidate will have the opportunity to ask their own research questions, answer these by analyzing the wealth of research data available in our lab and collaborators across the university and beyond, and process the ensuing results for publication and grant funding.

This position is grant funded.

Responsibilities:

  • Conduct preliminary statistical snalysis of project data and provide progress reports to the Principal Investigator as needed.
  • Responsible for independently overseeing and conducting phone screens, interviews, evaluations, assessments and/or tests with research participants.
  • Mentor, train and assist with supervising junior research staff as needed.
  • Responsible for the submission of regular reports detailing the progress of the research.
  • Discuss outcomes and participate in research and/or clinical decision making process.
  • Screen referrals.
  • Initiate research participant recruitment efforts and share responsibility of overseeing accurate data collection.
  • Assist with IRB and grant submissions as needed.
  • Assist with preparation of scientific articles as needed.

Qualifications

  • Master's Degree in Psychology, Neuroscience, Counseling, Sociology or related research field and 1 year of work experience in a research project and/or related clinical setting.

OR

  • Bachelor's Degree in Psychology, Neuroscience, Counseling, Sociology or related research field and 3 years of work experience in a research project and/or related clinical setting.
  • Familiarity with computers and common software packages required.
  • Working knowledge of research methodology strongly preferred.

Licensure, Certifications, and Clearances:

  • Act 34

UPMC is an Equal Opportunity Employer/Disability/Veteran

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