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Research Associate WPIC

Description

Purpose:
This study is geared toward cognitive deficits in individuals with schizophrenia and related diagnoses reflect altered GABA neurotransmission in the prefrontal cortex. The studies in our laboratory are geared at advancing our understanding of the disease process of schizophrenia by 1) identifying the affected GABA neurons using a novel, rigorous definition of GABA neuron subtypes, 2) informing on potential upstream signaling mechanisms that give rise to lower GAD67 expression specifically in these neurons and cell type-specific responses to this alteration, and 3) assessing dendritic spine densities across brain regions and cortical layers in schizophrenia and potential mechanisms for differences that are identified. Findings will provide both new insights into potential cell type-specific therapeutic targets and the foundation for future tests of mechanistic relationships in model systems. 

This position is grant funded.

Responsibilities:
  • Processing tissue for quantitative fluorescence microscopy and for multiplex fluorescence in situ hybridization.
  • Imaging tissue sections and slices using different microscopy techniques (e.g., confocal microscopy, super resolution microscopy, live cell microscopy).
  • Post image capture processing and data analysis.
  • Computer programming (Matlab and/or python) and running computer algorithms.
  • Maintain accurate documentation.

Qualifications

  • Bachelors degree required preferably in psychology or related field.
  • Familiarity with computers and common software packages required. 
  • Prior related work experience in a research setting preferred.
  • Working knowledge of research methodology strongly preferred.
Licensure, Certifications, and Clearances:
  • Act 34
UPMC is an Equal Opportunity Employer/Disability/Veteran

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   Current UPMC employees must apply in HR Direct